Bad Bone Marrow Could be the Culprit Behind Blood Diseases
Most scientists have long believed that disruptions in the routine life cycle of stem cells were responsible for the group of blood disorders known as myeloproliferative syndromes. However, new research now has them looking in a different direction: to faulty bone marrow.
According to two studies just published in the journal Cell, the disorders appear to be triggered by conditions inside the microenvironment which surrounds stem cells while they are being stored in the marrow rather than originating inside the cells themselves. The study teams, led by stem cell biologist Louise Purton and pediatric oncologist Stuart Orkin respectively, were both successful in quickly inducing blood disorders in normal mice by altering proteins in their marrow.
The researchers believe these findings may change how devastating blood diseases, such as leukemia, are diagnosed and treated in the future.
Source: Scientific American.com
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